Find the Cheapest Flights from Santo Domingo to Panama
Unlock the cheapest flights and the best airfares from Santo Domingo to Panama. Make your dream trip both memorable and affordable!
Santo Domingo to Panama: Flight information
Cheapest flight found$748
Cheapest month to flyApril
Most popular airlineCopa Airlines
Flights per week1
Popular Airlines flying from
Santo Domingo to Panama
From
Santo Domingo
Mar 18, 2023
To
Panama
oneway / Economy
$120
Viewed: 2 years ago
From
Santo Domingo
Jun 18, 2023
To
Panama
oneway / Economy
$130
Viewed: 2 years ago
From
Santo Domingo
Nov 23, 2025
To
Panama
oneway / Business
$405
Viewed: a month ago
From
Santo Domingo
Apr 03, 2024
To
Panama
oneway / Economy
$490
Viewed: a year ago
From
Santo Domingo
May 13, 2024
To
Panama
oneway / Economy
$503
Viewed: a year ago
From
Santo Domingo
Jan 29, 2024
To
Panama
oneway / Economy
$513
Viewed: a year ago
From
Santo Domingo
May 13, 2024
To
Panama
oneway / Economy
$544
Viewed: a year ago
From
Santo Domingo
Jan 21, 2024
To
Panama
oneway / Economy
$654
Viewed: a year ago
From
Santo Domingo
Jan 21, 2024
To
Panama
oneway / Economy
$654
Viewed: a year ago
From
Santo Domingo
Jan 28, 2024
To
Panama
oneway / Economy
$656
Viewed: a year ago
From
Santo Domingo
Apr 03, 2025
To
Panama
oneway / Business
$748
From
Santo Domingo
Jan 21, 2024
To
Panama
oneway / Economy
$1,055
Cheapest flight found
Feb 2024
N/A
Mar 2024
N/A
Jun 2024
N/A
Jul 2024
N/A
Aug 2024
N/A
Sep 2024
N/A
Oct 2024
N/A
Nov 2024
N/A
Dec 2024
N/A
Apr 2024
$490
Jan 2024
$513
May 2024
$544
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